Cellular Effects of Small Molecule PTP1B Inhibitors on Insulin Signaling †
✍ Scribed by Xie, Laiping; Lee, Seung-Yub; Andersen, Jannik N.; Waters, Steve; Shen, Kui; Guo, Xiao-Ling; Moller, Niels Peter H.; Olefsky, Jerrold M.; Lawrence, David S.; Zhang, Zhong-Yin
- Book ID
- 126856662
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 412 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0006-2960
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we
## Abstract Activation of the PI3K/Akt signaling pathway is correlated with poor prognosis in neuroblastoma, the most common and deadly extracranial tumor of childhood. In this study, we show that the small‐molecule inhibitors of phosphoinositide‐dependent protein kinase‐1 (PDK1) OSU03012 and the d