Cellular determinants of the mutational specificity of 1-nitroso-6-nitropyrene and 1-nitroso-8-nitropyrene in the lacI gene of Escherichia coli
β Scribed by I.B. Lambert; C. Carroll; N. Laycock; J. Koziarz; I. Lawford; L. Duval; G. Turner; R. Booth; S. Douville; J. Whiteway; M.R. Nokhbeh
- Book ID
- 114070493
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 806 KB
- Volume
- 484
- Category
- Article
- ISSN
- 0027-5107
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Forward mutations induced by 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in the supF gene of Escherichia coli were recovered from bacteria deficient in nucleotide excision repair and in DNA-alkyltransferase activity. Bacteria were exposed to 0.4 mM CCNU (in vivo supF mutagenesis), increasing
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