CPT-11 in human colon-cancer cell lines
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Willy J.M. Jansen; Bas Zwart; Saskia T.M. Hulscher; Giuseppe Giaccone; Herbert M
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Article
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1997
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John Wiley and Sons
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French
β 104 KB
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CPT-11, a new semisynthetic derivative of camptothecin, is active in a number of tumor types in the clinic, including colon cancer. CPT-11 is a drug that is converted into the active metabolite SN-38 by a carboxylesterase. Experiments were performed to obtain more insight in the cellular characteris