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Cellular cytotoxicity in transitional cell carcinoma of the human urinary bladder ? A summary

✍ Scribed by Perlmann, P. ;Troye, M. ;Pape, G. ;Blomgren, H. ;Johansson, B.

Publisher: Springer
Year: 1978
Tongue: English
Weight: 295 KB
Volume: 6
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00262619

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✦ Synopsis

The cytoxicity in vitro fo peripheral blood lymphocytes from patients with carcinoma of the urinary bladder (TCC-bladder) against allogeneic target cells from established cell lines was studied by the 51Cr-release assay. Lymphocytes from both untreated and treated TCC-bladder patients have a significantly elevated mean cytotoxicity to TCC-bladder target cells. Tumour cell destruction by lymphocytes from TCC-bladder patients shows a clear disease related specificity. In TCC-bladder patients a superimposed cytotoxicity exists, probably reflecting reactions against one or several tumour - associated antigens. In treated patients this cytotoxicity may be masked by higher incidence of cross reaction.

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