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Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid β-peptide

✍ Scribed by Shi Du Yan; Alex Roher; Michael Chaney; Berislav Zlokovic; Ann Marie Schmidt; David Stern


Book ID
117617739
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
757 KB
Volume
1502
Category
Article
ISSN
0925-4439

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## Abstract The amyloid‐β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β‐enriched secondary structure. Our strategy to i