Cellular cation transport studied by 6, 7Li and 23Na NMR in a porous Mo132 Keplerate type nano-capsule as model system
✍ Scribed by Dieter Rehder; Erhard T. K. Haupt; Achim Müller
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 301 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0749-1581
- DOI
- 10.1002/mrc.2343
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✦ Synopsis
Li + ions can interplay with other cations intrinsically present in the intra-and extra-cellular space (i.e. Na + , K + , Mg 2+ and Ca 2+ ) and have therapeutic effects (e.g. in the treatment of bipolar disorder) or toxic effects (at higher doses), likely because Li + interferes with the intra-/extra-cellular concentration gradients of the mentioned physiologically relevant cations. The cellular transmembrane transport can be modelled by molybdenum-oxide-based Keplerates, i.e. nano-sized porous capsules containing 132 Mo centres, monitored through 6/7 Li as well as 23 Na NMR spectroscopy. The effects on the transport of Li + cations through the 'ion channels' of these model cells, caused by variations in water amount, temperature, and by the addition of organic cationic 'plugs' and the shift reagent [Dy(PPP) 2 ] 7-are reported. In the investigated solvent systems, water acts as a transport mediator for Li + . Likewise, the counter-transport (