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Cellular automata simulation of medication-induced autoimmune diseases

✍ Scribed by Dietrich Stauffer; Ana Proykova

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
223 KB
Volume
331
Category
Article
ISSN
0378-4371

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✦ Synopsis

We implement the cellular automata model proposed by Stau er and Weisbuch in 1992 to describe the response of the immune system to antigens in the presence of medications. The model contains two thresholds, Γ‚1 and Γ‚2, suggested by de Boer, Segel, and Perelson to present the minimum ΓΏeld needed to stimulate the proliferation of the receptors and to suppress it, respectively. The in uence of the drug is mimicked by increasing the second threshold, thus enhancing the immune response. If this increase is too strong, the immune response is triggered in the whole immune repertoire, causing it to attack the own body. This e ect is seen in our simulations to depend both on the ratio of the thresholds and on their absolute values.

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