𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cellular and humoral immunity to rat hepatoma-specific antigens correlated with tumour status

✍ Scribed by R. W. Baldwin; M. J. Embleton; R. A. Robins

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
628 KB
Volume
11
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lymphocytes from rats bearing primary or transplanted aminoazo‐dye‐induced hepatomas were specifically cytotoxic for cells of the same tumour. Cytotoxic antibody was not present in the serum of these animals, although humoral factors capable of abrogating lymph‐node cell‐mediated cytotoxicity in vitro were detected. Following excision of transplanted hepatomas, cytotoxic lymph‐node cells were still demonstrable, with slightly increased reactivities comparable to those detected in a previous study of repeatedly immunized rats. Cytotoxic antibody was present in serum after tumour excision, and this correlates with the loss of serum blocking activity for lymph‐node cell‐mediated cytotoxic effects. In comparison, serum from rats repeatedly immunized to hepatomas, where high levels of cytotoxic antibody are also present, blocks lymph‐node cell‐mediated reactions in vitro, despite the immune status of the donor. These considerations suggest qualitative differences between the blocking factors in the serum of tumour‐bearer and tumour‐immune hosts, the former being antigen‐antibody complexes, and the latter free antibody.

📜 SIMILAR VOLUMES

Demonstration by colony inhibition metho
Demonstration by colony inhibition methods of cellular and humoral immune reactions to tumour-specific antigens associated with aminoazo-dye-induced rat hepatomas
✍ R. W. Baldwin; M. J. Embleton 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 576 KB

## Abstract Cellular and humoral immune reactions against tumour‐specific antigens on aminoazo‐dye‐induced rat hepatomas were demonstrated __in vitro__ by the colony inhibition technique. Lymph‐node cells from syngeneic rats immunized against individual hepatomas inhibited colony formation by cells

Serum factors modifying cell mediated im
Serum factors modifying cell mediated immunity to rat hepatoma D23 correlated with tumour growth
✍ J. G. Bowen; R. A. Robins; R. W. Baldwin 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 781 KB

## Abstract Sera from rats bearing a progressively growing transplanted aminoazo‐dye‐induced hepatoma (hepatoma D23) have been examined for the presence of hepatoma D23‐specific antigen, antibody and immune complexes throughout the course of tumour growth. The levels of these factors have been corr

Tumour antigens and alloantigens. II. La
Tumour antigens and alloantigens. II. Lack of association of rat hepatoma-D23-specific antigen with β2 microglobulin
✍ J. Gareth Bowen; R. W. Baldwin 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 672 KB

## Abstract It has previously been shown that the tumourspecific antigen of the chemically‐induced rat hepatoma D23 has determinants recognised by alloantisera raised against normal syngeneic liver and spleen. However, no reactions were observed with alloantisera raised against syngeneic erythrocyt

The humoral immune response to p53 in pa
The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the α-fetoprotein status
✍ Martin Volkmann; Martina Müller; Walter J. Hofmann; Martina Meyer; Jens Hagelste 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 795 KB

Recently, p53 gene aberrations have been recognized as a relevant factor in hepatocarcinogenesis, in tumors from both high-risk and low-risk areas. Because p53 gene mutations typically result in increased p53 levels in tumor cells, this cellular protein might become immunogenic during tumor developm

Tumor-antigen-specific humoral immune re
Tumor-antigen-specific humoral immune response of animals to anti-idiotypic antibodies and comparative serological analysis of patients with small-cell lung carcinoma
✍ Hans-Peter Lehmann; Caroline Zwicky; Robert Waibel; Rolf A. Stahel 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 782 KB

## Abstract We have previously developed 3 monoclonal anti‐idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small‐cell lung carcinoma (SCLC)‐associated sialoglycoprotein antigen sGP~90–135~. The aim of this study