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Cellular accumulation and cytotoxicity of macromolecular platinum complexes in cisplatin-resistant tumor cells

✍ Scribed by Dirk Garmann; André Warnecke; Ganna V. Kalayda; Felix Kratz; Ulrich Jaehde


Book ID
113691812
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
681 KB
Volume
131
Category
Article
ISSN
0168-3659

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## Abstract Cisplatin is a chemotherapeutic agent commonly used in the treatment of a wide variety of malignant tumors. Resistance to cisplatin represents a major obstacle to effective cancer therapy because clinically significant levels of resistance quickly emerge after treatment. Based on previo