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Cell-Type Specific DNA Methylation Patterns Define Human Breast Cellular Identity

✍ Scribed by Novak, Petr; Stampfer, Martha R.; Munoz-Rodriguez, Jose L.; Garbe, James C.; Ehrich, Mathias; Futscher, Bernard W.; Jensen, Taylor J.; Coleman, William B.


Book ID
120367254
Publisher
Public Library of Science
Year
2012
Tongue
English
Weight
924 KB
Volume
7
Category
Article
ISSN
1932-6203

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## Abstract O^6^‐Alkylguanine is a major toxic, mutagenic, and carcinogenic lesion in cellular DNA that is repaired by O^6^‐alkylguanine‐DNA alkyltransferase (ATase). The expression of this gene is directly related to the cellular sensitivity of alkylating agents, with levels of this protein varyin