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Cell type-dependent difference in the distribution and frequency of aphidicolin-induced fragile sites: T and B lymphocytes and bone marrow cells

✍ Scribed by Ichiro Murano; Akira Kuwano; Tadashi Kajii

Publisher
Springer
Year
1989
Tongue
English
Weight
340 KB
Volume
84
Category
Article
ISSN
0340-6717

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✦ Synopsis

The distribution and frequency of aphidicolin-induced common fragile sites were studied in Epstein-Barr virus-transformed B lymphocytes from eight normal individuals, and in bone marrow cells from six children in remission from malignant blood diseases. PHA-stimulated helper T lymphocytes from the same individuals were also studied. These cells were cultured in MEM, and treated with 0.2 microM aphidicolin for 26 h. The results, together with those of our previous study on cultured skin fibroblasts, indicated that the distribution and frequency of aphidicolin-induced fragile sites are different among different types of cells.

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Cell type-dependent difference in the distribution and frequency of excess thymidine-induced common fragile sites: T lymphocytes and skin fibroblasts
✍ Akira Kuwano; Ichiro Murano; Tadashi Kajii 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 317 KB

Common fragile sites were induced by excess thymidine in phytohemagglutinin-stimulated T lymphocytes from 4 normal individuals, and skin fibroblasts from 4 normal and 5 fra(X) positive individuals. The results indicate that the frequency and distribution of excess thymidine-induced fragile sites are