Cell to Cell Signals in Mammalian Development

✍ Scribed by Frank Schulze, Michael Kessel, Peter Gruss (auth.), S. W. de Laat, J. G. Bluemink, C. L. Mummery (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1989
• Tongue: English
• Leaves: 320
• Series: NATO ASI Series 26
• Edition: 1
• Category: Library

✦ Synopsis

Developmental biology deals with the regulatory principles underlying the generation of a new organism. The up-to-date knowledge of the molecular and cellular mechanisms that guide mammalian development from a single cell through a complex and integrated process of cell multiplication, differentiation and organisation of cells into tissues and organs is presented in this volume. Aspects of the molecular nature and developmental significance of cell-to-cell signals focus on: - hoxgenes, their products and potential role in mammalian morphogenesis; - growth factors, their receptors and signal transduction, and their role in guiding cell multiplication, differentiation and transformation; and - cell adhesion and extracellular matrix molecules, as short-range cell-to-cell signals in mammalian development.

✦ Table of Contents

Front Matter....Pages I-VIII
The Murine Homeobox Protein Hox 1.1 Is Differentially Expressed in Embryonal Mesoderm and Ectoderm....Pages 1-8
Structure, Expression and Evolutionary Relationships of Murine Homebox Genes in the Hox 2 Cluster....Pages 9-21
Regulation of Expression of the Hox 2.3 Gene....Pages 23-41
The Mouse En-1 Gene Encodes a Nuclear Protein Expressed in the Nervous System of the Developing Embryo....Pages 43-52
The Hox 1.3 Horneo Box Gene Encodes a Sequence Specific DNA Binding Phosphoprotein....Pages 53-61
Analysis of transcription of the murine homeobox gene Hox 1.3....Pages 63-73
The Human Cognate of the Murine Hox 1.3 Horneo Box Gene is Almost Identical to its Murine Counterpart....Pages 75-84
Temporal and Cellular Specificity of Expression of the Murine Homeobox-Containing Gene Hox-1.4 ....Pages 85-96
Murine Homeo-Genes: Some Aspects of their Organisation and Structure....Pages 97-108
Cell Adhesion in Morphogenesis....Pages 109-128
Generation of Diversity in the NCAM Adhesion Protein of Rodents....Pages 129-143
Ultrastructural Localization of the Cell Adhesion Molecule Uvomorulin using Site-directed Antibodies....Pages 145-152
Mutational Analysis of the EGF Receptor Proto-Oncogene....Pages 153-162
Activation of the Human Epidermal Growth Factor Receptor....Pages 163-181
Insulin receptor tyrosine kinase and insulin action....Pages 183-192
The Macrophage Colony Stimulating Factor, CSF-1, and Its Receptor (c- fms )....Pages 193-207
Signal Transduction by Growth Factor Receptors....Pages 209-217
Growth and Differentiation Factors of Embryonic Stem Cells....Pages 219-229
Regulation of Growth Factors and their Receptors in Early Murine Embryogenesis....Pages 231-245
Mesodermal Differentiation of Embryonal Carcinoma Cells in Coculture with Visceral Endoderm Cell Lines....Pages 247-260
Platelet-derived Growth Factor and its Role in Mitogenesis and Transformation....Pages 261-269
The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Rat Kidney Cells....Pages 271-288
Functions of the erbA and erbB Oncogenes in Avian Erythroblatosis....Pages 289-300
C- Fos and Polyoma Middle T Oncogene Expression in Transgenic Mice and Embryonal Stem Cell Chimaeras....Pages 301-310
Expression of Proto-oncogene int-1 is Restricted to Specific Regions of the Developing Mouse Neural Tube....Pages 311-317
Back Matter....Pages 319-324

✦ Subjects

Cell Biology; Cancer Research; Oncology