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Cell-to-cell contact is critical for the survival of hematopoietic progenitor cells on osteoblasts

✍ Scribed by Younghun Jung; Jianhua Wang; Aaron Havens; Yanxi Sun; Jingcheng Wang; Taocong Jin; R.S. Taichman

Book ID
116397649
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
321 KB
Volume
32
Category
Article
ISSN
1043-4666

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Osteoblasts (OBs) exert a prominent regulatory effect on hematopoietic stem cells (HSCs). We evaluated the difference in hematopoietic expansion and function in response to co-culture with OBs at various stages of development. Murine calvarial OBs were seeded directly (fresh) or cultured for 1, 2, o