Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: Tissue distribution in vivo and possible participation in specific cell-cell interaction
✍ Scribed by Rapp, U. R. ;Marshall, Thomas H.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1980
- Tongue
- English
- Weight
- 593 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0091-7419
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✦ Synopsis
Abstract
We have described previously the detection and tissue distribution of free cell surface receptors for ecotropic R‐MuLV envelope glycoprotein and the growth factor EGF in vivo [1]. More recently, we have reported the chromosomal map position of the ecotropic viral receptor and its conservation between subspecies of the genus Mus [2]. This work has shown, for the first time, the presence of multiple, independently segregating cell surface receptor genes specific for different classes of ecotropic type C viral envelope glycoprotein. In this report we extend these findings and identify chromosome 2 as coding for the receptor used by M813, an ecotropic MuLV from a feral Asian mouse. This new receptor is probably also used by oncogenic, recombinant (MCF class) MuLV of C3H origin.