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Cell surface glycoprotein analysis: A diagnostic tool in human leukemias

✍ Scribed by Leif C. Andersson; Carl G. Gahmberg; Martti A. Shmes; Lasse Teerenhovi; Pekka Vuopio

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
532 KB
Volume
23
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

We have radiolabelled surface glycoproteins of different types of leukemic cell. The labelled proteins were separated by polyacrylamide slab gel electrophoresis and visualized by fluorography. Surface glycoprotein patterns discriminatory for acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL). acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) were found. We conclude that the analysis of the surface glycoprotein profile provides a useful method for the classification of leukemic cells according to cell type and stage of differentiation.

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