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Cell stiffness, contractile stress and the role of extracellular matrix

✍ Scribed by Steven S. An; Jina Kim; Kwangmi Ahn; Xavier Trepat; Kenneth J. Drake; Sarvesh Kumar; Guoyu Ling; Carolyn Purington; Tirumalai Rangasamy; Thomas W. Kensler; Wayne Mitzner; Jeffrey J. Fredberg; Shyam Biswal

Book ID
116298439
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
482 KB
Volume
382
Category
Article
ISSN
0006-291X

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Matrix stiffness (resistance to deformation), one of the many mechanical forces acting on cells, is increasingly appreciated as an important mediator of cell behavior. It regulates cell signaling broadly, with effects on growth, survival, and motility. Although the stiffness optima for different kin