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Cell-specific regulation of plasminogen activator inhibitor 1 and tissue type plasminogen activator release by human kidney mesangial cells

✍ Scribed by Marie-Noëlle Peraldi; Eric Rondeau; Robert L. Medcalf; Jacqueline Hagège; Roger Lacave; Delarue Françoise; Wolf-Dieter Schleuning; Jean-Daniel Sraer


Book ID
119121612
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
582 KB
Volume
1134
Category
Article
ISSN
0167-4889

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## Abstract Although originally known as a plasma serine protease involved in clot dissolution, tPA and its primary inhibitor, PAI‐1, play crucial roles in synaptic reorganization and plasticity in the central nervous system. In contrast to the wide array of work conducted in neural cells, relative