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Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases

✍ Scribed by Leena H Tiitto; Mirva J Peltoniemi; Riitta L Kaarteenaho-Wiik; Ylermi M Soini; Paavo K Pääkkö; Raija T Sormunen; Vuokko L Kinnula

Book ID
116533738
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
606 KB
Volume
35
Category
Article
ISSN
1532-8392

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✍ Tetsuya Iida; Eri Mori; Katsuharu Mori; Shinji Goto; Yoshishige Urata; Mikio Oka 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 178 KB

Glutathione (␥-glutamylcysteinyl glycine, GSH) is believed to be important in the acquisition of resistance to anti-cancer drugs such as cisplatin (CDDP) and doxorubicin (DOX). ␥-Glutamylcysteine synthetase (␥-GCS) is a key enzyme for maintaining intracellular GSH levels; it is composed of a catalyt