Cell Specific Peptide-Conjugated Polysaccharide Nanogels for Protein Delivery

✍ Scribed by Asako Shimoda; Shin-ichi Sawada; Kazunari Akiyoshi

• Book ID: 102934889
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 539 KB
• Volume: 11
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.201000491

✦ Synopsis

Abstract

A cell specific peptide (Arg‐Gly‐Asp; RGD)‐modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD‐modified nanogel complex was efficiently internalized into cells through integrin‐mediated endocytosis. Endosomal escape of the RGD‐modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.
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