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Cell-specific effects of RAS oncogene and protein kinase C agonist TPA on P-glycoprotein function

✍ Scribed by T.P. Stromskaya; I.A. Grigorian; V.S. Ossovskaya; E.Y. Rybalkina; P.M. Chumakov; B.P. Kopnin

Book ID
115931030
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
334 KB
Volume
368
Category
Article
ISSN
0014-5793

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The four fluorescent derivatives of TPA-dansylaza-TPA, NBDaza-TPA, and (N)and (P)-dansylamino-TPA-were synthesized and examined for their ability to induce differentiation in human promyelocytic leukemic HL60 cells. At a concentration of 20 nM, all the derivatives inhibited proliferation and induced