Cell signaling cascades regulating restoration of neuronal network following injury to the central nervous system

The deployment of adenovirus-containing

The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies

✍ Ana Maria Gonzalez; Oscar Berlanga; Wendy E. Leadbeater; Lisa Cooper-Charles; Ka 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB 👁 1 views

## Abstract ## Background In previous studies, we showed that gene activated matrices (GAMs) containing nonviral vectors successfully deliver genes to neurons after optic nerve and spinal cord injury. In the present study, we evaluated whether adenoviral vectors delivered within a GAM increase the