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Cell responses to biomaterials II: Endothelial cell adhesion and growth on perfluorosulfonic acid

✍ Scribed by McAuslan, B. R. ;Johnson, G. ;Hannan, G. N. ;Norris, W. D. ;Exner, T.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
859 KB
Volume
22
Category
Article
ISSN
0021-9304

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✦ Synopsis

We report here the use of perfluorosulfonic acid (Nafion) as a substratum for the growth of bovine aortal endothelial cells. This support which can be generated in a number of forms is at least as efficient in maintaining the growth of endothelial and other cell types as tissue culture grade polystyrene (TCI') and represents an advance in this regard over polytetrafluoroethylene (Teflon). The mechanism underlying the different cell attachment capacities of these three polymers is not readily related to their different protein binding patterns. While Nafion adsorbs more total protein from serum than Teflon or TCP, it adsorbs relatively less of the major cell adhesive proteins, vitronedin and fibronectin, than does Teflon. Both Nafinn and Teflon had comparable but low thrombogenic potential by in vifro tests. Teflon or expanded Teflon (Gore-tex) coated with a thin film of Nafion assumes the cell supportive characteristics of Nafion and hence the modification of these surfaces by the induction of a stable bond between Teflon (in various forms) and Nafion may provide a composite vascular graft material which has all the desirable qualities of both materials.

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