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Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

✍ Scribed by Noemí Rueda; Ricardo Mostany; Ángel Pazos; Jesús Flórez; Carmen Martínez-Cué

Book ID
116767541
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
176 KB
Volume
380
Category
Article
ISSN
0304-3940

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Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice
✍ Andrea Contestabile; Tatiana Fila; Claudio Ceccarelli; Paola Bonasoni; Laura Bon 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 745 KB

## Abstract Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal o