✦ LIBER ✦

Cell proliferation in the respiratory tract of the rat after acute inhalation of formaldehyde or acrolein

✍ Scribed by E. Roemer; H. J. Anton; R. Kindt

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 465 KB
Volume: 13
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550130206

No coin nor oath required. For personal study only.

✦ Synopsis

Male Sprague Dawley rats were exposed by inhalation for 6 h per day on one or three successive days to 0, 2, 6 or 20 ppm formaldehyde or 0, 0.2 or 0.6 ppm acrolein. Nasal and tracheal epithelial and free lung cells were then analyzed for proliferative responses. The proliferative response was expressed as the proportion of DNA synthesizing cells determined by the 5-bromodeoxyuridine (BrdU) labeling technique.

Single exposure to both irritants increased the DNA synthesizing (proliferating) cells by a factor of 3. After three exposures the increase was distinctly lower. All sites analyzed showed approximately the same concentratiodresponse pattern. Significant changes in cell proliferation could be detected at 2 ppm formaldehyde and 0.2 ppm acrolein.

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