Cell Proliferation, Carbohydrate Breakdown, and Hydration of Enzyme Protein
β Scribed by LASNITZKI, A.
- Book ID
- 109546854
- Publisher
- Nature Publishing Group
- Year
- 1945
- Tongue
- English
- Weight
- 130 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/156398a0
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Cell density negative control (CDNC) of normal human fibroblast proliferation occurs after stimulation by mitogens with different signal transduction mechanism. Delayed exposure to agents that interfere with CDNC, such as doublestranded RNA and vanadate, reveals the existence of a biochemical event,
Phorbol 12-myristate 13-acetate (PMA) has been shown to stimulate DNA synthesis and cell proliferation in a population of glial cells isolated from newborn rat brain. The non-tumor promoter 4a-phorbol l2,13-didecanoate (4a-PDD), on the other hand, was without an effect. The cultures treated with PMA