✦ LIBER ✦

Cell plasticity in Caenorhabditis elegans: From induced to natural cell reprogramming

✍ Scribed by Martina Hajduskova; Arnaud Ahier; Thomas Daniele; Sophie Jarriault

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 467 KB
Volume: 50
Category: Article
ISSN: 1526-954X
DOI: 10.1002/dvg.20806

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Achieving controlled reprogramming of differentiated cells into a desired cell type would open new opportunities in stem‐cell biology and regenerative medicine. Experimentation on cell reprogramming requires a model in which cell conversion can be induced and tracked individually. The tiny nematode, Caenorhabditis elegans, owing to its known cellular lineage, allows the study of direct cell type conversion with a single‐cell resolution. Indeed, recent advances have shown that despite its invariant cell lineage, cellular identities can be reprogrammed, leading to cell conversion in vivo. In addition, natural transdifferentiation events occur in the worm, providing a powerful model for the study of cellular plasticity in a physiological cellular microenvironment. Here, we review pioneer studies on induced and naturally occurring reprogramming events in C. elegans and the new notions that have emerged. genesis 50:1‐17, 2012. © 2011 Wiley Periodicals, Inc.

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