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Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL

✍ Scribed by Vieira, Helena LA; Boya, Patricia; Cohen, Isabelle; El Hamel, Chahrazed; Haouzi, Delphine; Druillenec, Sabine; Belzacq, Anne-Sophie; Brenner, Catherine; Roques, Bernard; Kroemer, Guido

Book ID
110066477
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
557 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Background: Inhibition of apoptosis, or programmed cell death, may be critical both in the development of cancer and in determining response to therapy. the authors examined the expression of two related apoptotic inhibitors, bcl-2 and bcl-xl, in pretreatment biopsies from a series of 42 patient