Cell penetrating peptides: overview and applications to the delivery of oligonucleotides
โ Scribed by F. Said Hassane; A. F. Saleh; R. Abes; M. J. Gait; Bernard Lebleu
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 396 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Rerouting the splicing machinery with stericโblock oligonucleotides (ON) might lead to new therapeutic strategies in the treatment of diseases such as ฮฒโthalassemia, Duchenne muscular dystrophy, or cancers. Interfering with splicing requires the sequenceโspecific and stable hybridizatio
Drug delivery strategies using cell-penetrating peptides (CPPs) have been widely explored to improve the intracellular delivery of a large number of cargo molecules. Electrostatic complexation of plasmid DNA using CPPs has been less explored due to the relatively large complexes formed and the low l