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Cell Migration Rate on Poly(ε-caprolactone)/Poly(ethylene glycol) Diblock Copolymers and Correlation with the Material Sliding Angle

✍ Scribed by Shan-hui Hsu; Cheng-Ming Tang; Jeng-Jiann Chiu; Tien-Chi Liao; Chu-Chieh Lin; Hiroo Iwata

Book ID: 102471859
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 492 KB
Volume: 7
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.200600248

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✦ Synopsis

Abstract

The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real‐time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.

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