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Cell membrane translocation of the N-terminal (1–28) part of the prion protein

✍ Scribed by P Lundberg; M Magzoub; M Lindberg; M Hällbrink; J Jarvet; L.E.G Eriksson; Ü Langel; A Gräslund


Book ID
117052872
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
205 KB
Volume
299
Category
Article
ISSN
0006-291X

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## Abstract In the physiological form, the prion protein is a glycoprotein tethered to the cell surface via a C‐terminal glycosylphosphatidylinositol anchor, consisting of a largely α‐helical globular C‐terminal domain and an unstructured N‐terminal portion. This unstructured part of the protein co