𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell-mediated immunity in human acute myeloblastic leukemia

✍ Scribed by C. Pauli; F. Vànky; R. Hast; C. Lindemalm; A. M. Udén; P. Reizenstein

Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
757 KB
Volume
5
Category
Article
ISSN
0340-7004

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✦ Synopsis

Lymphocyte stimulation tests with autologous myeloblasts were performed in 31 patients with nonlymphatic acute leukemia. Twenty-five patients were receiving chemotherapy combined with immunotherapy; six received chemotherapy only. Thirteen nonleukemic patients with various disorders and six healthy control patients were also studied.

It was found that 4/15 patients in 9/38 tests had autologous lymphocytes stimulated by autologous circulating myeloblasts. Bone marrow cells also effected stimulation, significantly more often if the marrow was taken in relapse than when it was taken in remission.

However, so-called immunotherapy with allogeneic leukemic myeloblasts and BCG couM not be shown to increase these frequeneies. Nor did it significantly increase the degree of stimulation measured as DNA synthesis in lymphocytes.

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