𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell-mediated immunity following experimental vaccinations withCandida albicansribosomes

✍ Scribed by Ruth Levy; Esther Segal; Emanuel Eylan; Liliane Barr-Nea

Book ID
104773039
Publisher
Springer Netherlands
Year
1983
Tongue
English
Weight
896 KB
Volume
83
Category
Article
ISSN
0301-486X

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✦ Synopsis

The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.

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