Cell-mediated immunity against antigens common to human colonic carcinomas and fetal gut Epithelium
✍ Scribed by Ingegerd Hellström; Karl Erik Hellström; Thomas H. Shepard
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- French
- Weight
- 460 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Blood lymphocytes from human patients with adenocarcinomas of the colon inhibited colony formation of plated cells from colon carcinomas, but not of cells from normal adult colon mucosa, as compared to control lymphocytes from patients who did not have cancer or who had neoplasms other than colon carcinomas. Lymphocytes from patients with colon carcinomas also inhibited plated fetal gut and liver epithelial cells, while they did not inhibit fetal kidney cells. The data thus indicated that colon carcinomas, fetal gut and fetal liver cells have an antigen in common, absent from adult colon and fetal kidney, and that lymphocytes from patients with colonic carcinomas are immune to that antigen.