Cell-Mediated autoimmunity at the onset of insulin-dependent diabetes mellitus (IDDM)
β Scribed by Ziegler, A. G. ;Standl, E. ;Lander, T. ;Nerl, Ch. ;Rieber, E. P. ;Mehnert, H.
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 530 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1432-1440
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Immunocompetent antigen-presenting Langerhans cells were investigated in skin biopsies of 20 short-term Type 1 (insulin-dependent) diabetic patients and compared with 17 matched normal control subjects. Langerhans cells in epidermal sheet preparations were visualized with a monoclonal anti-HLA DR an
Percentages of various T-lymphocyte subpopulations in the blood were studied at the onset of Type 1 (insulin-dependent) diabetes. The number of lymphocytes with OKT8 markers was higher in the diabetic patients than in control subjects (p less than 0.005) and the ratio between helper and suppressor/c