Children with acute lymphocytic leukemia negative. In two patients E-rosettes could not (ALL) who have a "lymphoma syndrome" be accurately determined because of a low (LySLk) defined by the presence of at least percentage of lymphoblasts in the samples three of the following criteria: a) Hg > 10 g/ studied. Follow-up data on CALLA-positive and dl, b) lymph nodes > 3 cm, c) spleen below CALLA-negative patients revealed 414 CALLAumbilicus, d) liver below umbilicus, and e) positive patients with no evidence of disease mediastinal mass, appear to represent a (NED) at 22+ to 45+ months from diagnosis subgroup of ALL. These children have a poor and 2/16 CALLA-negative patients NED at 19+ prognosis for survival when treated with and 57+ months. Thus it appears that the standard chemotherapy for ALL. We per-majority of children with LySLk have lymphoformed a retrospective review of 21 patients blasts which are CALLA negative. Patients who at Children's Memorial Hospital with LySLk meet clinical criteria for LySLk but whose surdiagnosed from Jan 24,1977 to July 8,1981 and face markers are E negative, CALLA positive of the surface markers on their leukemic cells may have a better prognosis and may repreat diagnosis. Surface markers identified in-sent a separate subgroup of patients with ALL cluded E-rosettes (E), surface immunoglobulin and, therefore, should be given therapy ap-(Slg), and common ALL antigen (CALLA). Four propriate for their prognostic classification by patients were CALLA positive and E-rosette more standard criteria, such as white blood negative; nine patients were E-negative, CALLA count, age, and sex. negative; six patients were E positive, CALLA