Cell lineages in hematopoietic neoplasia studied with glucose-6-phosphate dehydrogenase cell markers

✍ Scribed by Philip J. Fialkow

• Book ID: 102882287
• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 651 KB
• Volume: 113
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041130409

✦ Synopsis

Hematologic stem cells pluripotent for lymphoid and myelogenous cells have not been identified directly in humans. However, several indirect approaches have been used to study this question. For example, the existence of a progenitor pluripotent for lymphoid as well as myeloid cells is suggested by the finding of both cell types in individual, presumably clonal, colonies grown in vitro from human marrow (Messner et al., 1981). The indirect method used in the work reviewed here is based upon study of hematologic neoplasms arising in females whose X-chromosome inactivation mosaicism is delineated with glucose-6-phosphate dehydrogenase (GGPD) markers. Since the G6PD locus is on the X