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Cell killing by various nitrosoureas and the potentiating effect of caffeine

✍ Scribed by Regine Goth-Goldstein

Book ID
113192402
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
384 KB
Volume
94
Category
Article
ISSN
0027-5107

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Synchronous populations of HeLa S3 cells suffer synergistic killing during S phase in the presence of 0.5-5 mM hydroxyurea together with 5-10 mM caffeine. Both the rate and the extent of killing are greater than expected for independent action of the two drugs. Only simultaneous treatment is effecti