Cell Inactivation by Ionizing Particles and the Shapes of Survival Curves

✍ Scribed by L. JUDAS; M. LOKAJÍČEK

• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 209 KB
• Volume: 210
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.2001.2283

✦ Synopsis

Recent experiments concerning the survival of monolayer cells irradiated by di!erent parts of ion Bragg peaks opened a way to a deeper mechanistic understanding of cell inactivation. A new theoretical formula for survival curves has been derived re#ecting two basic phases of the given mechanism, i.e. energy transfer to a cell nucleus and subsequent biological e!ect (depending on the amount of imparted energy). The survival ratio for a given dose has been expressed as a function of inactivation probabilities of individual cells after di!erent numbers of nucleus hits (a given amount of energy being transferred to a cell nucleus in each ion traversal). Having used the experimental data for V79 cells irradiated by protons, deuterons and helium ions in di!erent parts of Bragg peaks preliminary values of these inactivation probabilities for individual cells at di!erent LET values have been established.