Cell Growth and Oncogenesis

✍ Scribed by A. Rempel, S. P. Mathupala, P. L. Pedersen (auth.), Prof. Dr. med. Peter Bannasch, Prof. Dr. Darja Kanduc, Prof. Dr. Sergio Papa, Prof. J. M. Tager (eds.)

• Publisher: Birkhäuser Basel
• Year: 1998
• Tongue: English
• Leaves: 314
• Series: Molecular and Cell Biology Updates
• Edition: 1
• Category: Library

✦ Synopsis

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. This book comprises recent results on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolism pathways during oncogenesis.

✦ Table of Contents

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Glucose catabolism in cancer cells: Role and regulation of hexokinase overexpression....Pages 3-14
Double role of pyruvate kinase type M 2 in the regulation of phosphometabolite pools....Pages 15-30
The mitochondrial ATP synthase in normal and neoplastic cell growth....Pages 31-46
The pH of internal compartments of normal and activated cells....Pages 47-55
Front Matter....Pages 57-57
Hepatic regeneration: New concepts on cell proliferation....Pages 59-73
Raf-dependent signaling pathways in cell growth and differentiation....Pages 75-95
E7 protein of human papillomaviruses and its interaction with cellular pathways....Pages 97-107
Phosphorylation of the p53 tumour suppressor protein by stress- and DNA damage-activated protein kinases....Pages 109-115
Bile acids, cell proliferation and protein phosphorylation....Pages 117-128
Alteration of cell division cycle regulation in human cancers: The role of CDKN2A gene....Pages 129-138
The bombesin receptor is coupled to multiple signal transduction pathways and induces cell proliferation....Pages 139-159
Control of cell proliferation by α-tocopherol....Pages 161-176
Development of resistance to the mitoinhibitory effects of orotic acid during experimental liver carcinogenesis....Pages 177-188
Front Matter....Pages 189-189
Early aberrations of energy metabolism in carcinogenesis....Pages 191-212
Stimulation of liver cell growth by direct mitogens....Pages 213-225
Low-number intrahepatic islet transplantation — a model of hormonal hepatocarcinogenesis....Pages 227-245
Translational regulation: possible significance of differential tRNA expression during the transition from quiescence to proliferation....Pages 247-256
Cloning and expression of a stable ornithine decarboxylase form conferring selective growth advantage to the HMO A cells against cytostatic treatment with α-methylornithine....Pages 257-265
Changing the lipid composition in hepatoma cell membranes can affect cell death and proliferation....Pages 267-278
The multidrug resistance phenotype: P-glycoprotein, regulation of the mdr genes and other related mechanisms....Pages 279-307
Back Matter....Pages 308-312

✦ Subjects

Medicine/Public Health, general