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Cell Growth and Monoclonal Antibody Production in the Presence of Antigen and Serum

✍ Scribed by Gregory Dandulakis; John C. Herr; Donald J. Kirwan


Book ID
114420676
Publisher
American Institute of Chemical Engineers
Year
1995
Tongue
English
Weight
810 KB
Volume
11
Category
Article
ISSN
8756-7938

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A quantitative study of the influence of initial serum concentration on hybridoma growth rate, maximum viable and total cell yield, and specific antibody production rate is presented. The specific growth rate varied in a Monod fashion with initial serum levels (2-10Β°/0 FCS), giving K,,, = 1.6 v/v% a