𝔖 Bobbio Scriptorium
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Cell growth and division: a deterministic/probabilistic model of the cell cycle

✍ Scribed by John J. Tyson; Kenneth B. Hannsgen

Publisher
Springer
Year
1986
Tongue
English
Weight
817 KB
Volume
23
Category
Article
ISSN
0303-6812

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✦ Synopsis

A model of the cell cycle, incorporating a deterministic cell-size monitor and a probabilistic component, is investigated. Steady-state distributions for cell size and generation time are calculated and shown to be globally asymptotically stable. These distributions are used to calculate various statistical quantities, which are then compared to known experimental data. Finally, the results are compared to distributions calculated from a Monte-Carlo simulation of the model.

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How does a Drosophila wing grow to the appropriate size and shape? Although a collaboration of cell division with the patterning of cell fates seems obvious, almost nothing is known about how these two processes are coordinated during development. A recent paper 1 finds that blocking cell division u