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Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines

✍ Scribed by P.R. Prince; C.E. Ogburn; M.J. Moser; M.J. Emond; G.M. Martin; R.J. Monnat Jr


Book ID
106137262
Publisher
Springer
Year
1999
Tongue
English
Weight
103 KB
Volume
105
Category
Article
ISSN
0340-6717

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We introduced the mutant p53 zene (codon 273Ar9-His) into human fibroblasts (SUSM-I ceils) previously immortalized with 4-nitroquinoline I -oxide (4NQO) and obtained 2 clonal cell lines (SUSM-I /p53-I and SUSM-l/p53-6) expressing the mutant p53. Since the genetic background of SUSM-l/p53 is the same