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Cell division and sister chromatid exchanges in 45,X/46,X,i(Xq) mosaicism

✍ Scribed by Kyra Michalová; Jana Málková; Josef Urban

Publisher: Springer
Year: 1977
Tongue: English
Weight: 222 KB
Volume: 39
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00273155

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✦ Synopsis

The kinetics of cell division and sister chromatid exchanges were studied in PHA-stimulated short-term cultivations of peripheral blood by means of the BUDR/FPG technique in controls and in five patients with 45,X/46,X,i(Xq) mosaicism. No significant difference in the length of the cell cycle were observed between 45,X/46,X,i(Xq) and control 46,XX cells. The number of SCE on late i(Xq) was only nonsignificantly elevated (0.6 per i(Xq) against the value expected on the basis of its relative length.

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