Stable formation of mutated p53 multimer
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Laura Ottaggio; Paola Campomenosi; Gilberto Fronza; Paola Menichini; Mariangela
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Article
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2006
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John Wiley and Sons
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English
⚖ 290 KB
## Abstract We have previously described a methotrexate‐resistant cell line (MTX M) characterized by amplified dihydrofolate reductase (__DHFR__) genes, cytoplasmic p53 localization, and p53 stable tetramers. To investigate the p53 functionality in MTX M, the effect of chemical/physical agents was