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Cell death and lipid peroxidation in isolated hepatocytes incubated in the presence of hydrogen peroxide and iron salts

✍ Scribed by Isabelle Latour; Jean-Louis Pregaldien; Pedro Buc-Calderon

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
692 KB
Volume
66
Category
Article
ISSN
0340-5761

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tert–butylhydroperoxide—Induced toxicity
tert–butylhydroperoxide—Induced toxicity in isolated hepatocytes: Contribution of thiol oxidation and lipid peroxidation
✍ Jewell, Sarah A. ;Monte, Donato Di ;Richelmi, Plinio ;Bellomo, Giorgio ;Orrenius 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

Incubation of isolated rat hepatocytes with tert-butylhydroperoxide resulted in marked cytotoxicity preceded by intracellular glutathione depletion and extensive lipid peroxidation. Addition of antioxidants delayed, but did not prevent, this toxicity. A significant decrease in protein-free sulfhydr