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Cell cycle molecules and vertebrate neuron death: E2F at the hub

✍ Scribed by Greene, L A; Biswas, S C; Liu, D X

Book ID: 110016662
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 169 KB
Volume: 11
Category: Article
ISSN: 1350-9047
DOI: 10.1038/sj.cdd.4401341

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## Abstract The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription‐dependent and ‐independent mechanisms. Recently, an E2F1 mutant lacking the DNA binding domain, E2F1(180–437), has been implicated in degradation of MDMX and MDM2 proteins via lysosom