✦ LIBER ✦

Cell cycle kinetics analysis of Hela cells exposed to aphidicolin: Computer simulation

✍ Scribed by Seraj Y. Abed; Sufian M. ElAssouli; Osman S. Ozkul; Mustafa Alidrisi; Majed Amer

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 612 KB
Volume: 22
Category: Article
ISSN: 0010-4825
DOI: 10.1016/0010-4825(92)90066-v

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✦ Synopsis

A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Noy et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G1/S boundary and that recruitment and synchrony occurred.

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