Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression
β Scribed by Vuocolo, Scott; Masciullo, Valeria; Sava, Teodoro; Giordano, Antonio; Soprano, Dianne Robert; Soprano, Kenneth J; Zhang, Dongmei
- Book ID
- 110066203
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 394 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have used conformationally restricted retinoids to investigate the role of individual RAR subtypes and RXR in mediating the growth response of ovarian tumor cells to retinoids. Our results show that treatment of all-trans-RA-sensitive CAOV-3 cells with retinoids that bind and activate a single RA
## Abstract Apoptosis is also known as programmed cell death. Apoptosis plays an essential role in maintaining normal tissue and cell physiology in multicellular organisms. Clearance of aberrant or preβcancerous cells occurs through the induction of apoptosis. It has been reported that many tumors
## Abstract We have investigated the mechanisms by which allβtrans retinoic acid (ATRA) causes growth inhibition of ovarian carcinoma cells. As a model, we have studied the CAOV3 cell line, which is sensitive to ATRA, and the SKOV3 cell line, which is resistant. We have found that treatment of CAOV