Cell cycle dependent gene expressions and activities of protein phosphatases PP1 and PP2A in mouse NIH3T3 fibroblasts
β Scribed by Koji Nakamura; Toshiaki Koda; Mitsuaki Kakinuma; Shu-ichi Matsuzawa; Kazuki Kitamura; Yusuke Mizuno; Kunimi Kikuchi
- Book ID
- 117055703
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 656 KB
- Volume
- 187
- Category
- Article
- ISSN
- 0006-291X
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Protein tyrosine phosphatases (PTPases) represent a family of enzymes which together with protein tyrosine kinases (PTKases) play a critical role in cell proliferation and are likely involved in neoplastic transformation. Results presented here indicate that PTPases may also be involved in mechanism
## Abstract S100A6 (calcyclin) is a calcium binding protein with two EFβhand structures expressed mostly in fibroblasts and epithelial cells. We have established a NIH 3T3 fibroblast cell line stably transfected with siRNA against S100A6 to examine the effect of S100A6 deficiency on nonβtransformed