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Cell cycle dependence of cytotoxicity and clastogenicity induced by treatment of synchronized human diploid fibroblasts with sodium fluoride

✍ Scribed by Nobuko Hayashi; Takeki Tsutsui


Book ID
113194392
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
927 KB
Volume
290
Category
Article
ISSN
0027-5107

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The cytotoxic effect of a direct perturbation of DNA during various portions of the DNA synthetic period (S phase) of cultured human diploid fibroblasts was examined. The cells were synchronized by a period of growth in low serum with a subsequent blockage of the cells at the GI/S boundary by hydrox